Porcine endogenous retroviruses: an obstacle to cross during xenotransplantation
نویسندگان
چکیده
Background Xenotransplantation involves the transplantation of nonhuman tissue or organs to humans. Worldwide shortage of organs for clinical applications has shifted the focus towards non-human sources. Pig represents a rich source of organ donors but the presence of porcine endogenous retroviruses (PERVs) represents a particular risk and considered as a major obstacle during xenotransplantation. Among various types; PERV-C may recombine to form recombinant PERV-A/C and has the ability to infect human cells invitro and replicate at high titers. Our study aims to screen porcine tissue samples for provirus and virus particles of PERVs by PCR and reverse transcriptase PCR (RT-PCR).
منابع مشابه
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